Brand  (β version)

PDB ID: 4GLS

Hetero Atom Contents

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
Non-standard Residues
Code Name Show
DAL D-alanine
DAR D-arginine
DAS D-aspartic acid
DCY D-cysteine
DGL D-glutamic acid
DGN D-glutamine
DHI D-histidine
DIL D-isoleucine
DLE D-leucine
DLY D-lysine
DPN D-phenylalanine
DPR D-proline
DSG D-asparagine
DSN D-serine
DTH D-threonine
DTR D-tryptophan
DTY D-tyrosine
DVA D-valine
MED D-methionine
Glycosylation
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Modification
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Structure summary

Code : 4GLS   PDBj   RCSB PDB   PDBe
Header : Growth Factor/Inhibitor
Title : Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21
Release Data : 2012-09-05
Compound :
mol_id molecule chains
1 D- Vascular endothelial growth factor-A A,B
mol_id molecule chains
2 L- RFX001 C,G
mol_id molecule chains
3 D- RFX001 D,H
mol_id molecule chains synonym
4 Vascular endothelial growth factor A E,F VEGF-A, Vascular permeability factor, VPF
Source :
mol_id organism_scientific
1
synthetic: yes
other_details: Chemical Synthesis
mol_id organism_scientific
2
synthetic: yes
other_details: Chemical Synthesis
mol_id organism_scientific
3
synthetic: yes
other_details: Chemical Synthesis
mol_id organism_scientific organism_common
4 Homo sapiens  (taxid:9606) Human
synthetic: yes
other_details: Chemical Synthesis
Authors : Mandal, K., Uppalapati, M., Ault-Riche, D., Kenney, J., Lowitz, J., Sidhu, S., Kent, S.B.H.
Keywords : heterochiral protein-protein complex, D-protein antagonist, Growth Factor-Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.

Mandal, K.,Uppalapati, M.,Ault-Riche, D.  et al.
(2012)  Proc.Natl.Acad.Sci.USA  109 : 14779 - 14784

PubMed: 22927390
DOI: 10.1073/pnas.1210483109

Reaction

Chain : E, F
UniProt : P15692 (VEGFA_HUMAN)
Reaction : -