Het-PDB Navi2 (PDB: 4GIH)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
0X5	2,6-dichloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 4GIH

Code :

4GIH PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Tyk2 (JH1) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE

Release Data :

2013-06-19

Compound :

mol_id	molecule	chains
1	Non-receptor tyrosine-protein kinase TYK2	A
	ec: 2.7.10.2 fragment: Kinase domain, UNP residues 885-1176 mutation: C936A, Q969A, E971A, K972A, D1023N, C1142A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: TYK2 expression_system_common: Fall armyworm

Authors :

Ultsch, M.H.

Keywords :

Tyrosine Kinase, Kinase, ATP Binding, Inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

Lead identification of novel and selective TYK2 inhibitors.

Liang, J.,Tsui, V.,Van Abbema, A. et al.
(2013) Eur.J.Med.Chem. 67 : 175 - 187

Chain :

UniProt :

P29597 (TYK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PubMed:10542297, PubMed:7526154
	-	PubMed:10542297, PubMed:7526154

PDB ID: 4GIH