Het-PDB Navi2 (PDB: 4GHI)

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Ligands
Code	Name		Style	Show	Link
0X3	N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine				PoSSuM

Non-standard Residues
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Download interaction data: 4GHI

Code :

4GHI PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a benzoxadiazole antagonist

Release Data :

2013-02-27

Compound :

mol_id	molecule	chains	synonym
1	Endothelial PAS domain-containing protein 1	A	EPAS-1, Basic-helix-loop-helix-PAS protein MOP2, Class E basic helix-loop-helix protein 73, bHLHe73, HIF-1-alpha-like factor, HLF, Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha, Member of PAS protein 2, PAS domain-containing protein 2
	fragment: C-terminal PAS domain, UNP residues 239-350 mutation: R247E

mol_id	molecule	chains	synonym
2	Aryl hydrocarbon receptor nuclear translocator	B	ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta
	fragment: C-terminal PAS domain, UNP residues 356-470 mutation: E362R

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: BHLHE73, EPAS1, HIF2A, MOP2, PASD2 expression_system_strain: BL21(DE3)CodonPlus expression_system_vector_type: plasmid expression_system_plasmid: pHIS-GB1-parallel

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: ARNT, BHLHE2 expression_system_strain: BL21(DE3)CodonPlus expression_system_vector_type: plasmid expression_system_plasmid: pHIS-GB1-parallel

Authors :

Scheuermann, T.H., Key, J., Tambar, U.K., Bruick, R.K., Gardner, K.H.

Keywords :

PAS Fold, protein : protein interactions, TRANSCRIPTION

Exp. method :

X-RAY DIFFRACTION ( 1.50 Å )

Citation :

Allosteric inhibition of hypoxia inducible factor-2 with small molecules.

Scheuermann, T.H.,Li, Q.,Ma, H.W. et al.
(2013) Nat.Chem.Biol. 9 : 271 - 276

PDB ID: 4GHI