Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0X2 2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide
Modified Residues
Code Name Link
PTR O-phosphotyrosine
Code : 4GFM
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : JAK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE
Release Data : 2013-06-19
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase JAK2 A Janus kinase 2, JAK-2
ec: 2.7.10.2
fragment: JH1 domain, UNP residues 833-1132
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: JAK2
Authors : Eigenbrot, C., Ultsch, M.
Keywords : o-phosphotyrosine, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Lead identification of novel and selective TYK2 inhibitors.

Liang, J.,Tsui, V.,Van Abbema, A.  et al.
(2013)  Eur.J.Med.Chem.  67 : 175 - 187

PubMed: 23867602
DOI: 10.1016/j.ejmech.2013.03.070

Chain : A
UniProt : O60674 (JAK2_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.