Het-PDB Navi2 (PDB: 4GAH)

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Ligands
Code	Name		Style	Show	Link
0ET	[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3r)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-[(2r)-2-oxidanylundecyl]sulfanylethylamino]propyl]amino]butyl] hydrogen phosphate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4GAH

Code :

4GAH PDBj RCSB PDB PDBe

Header :

hydrolase/hydrolase inhibitor

Title :

Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor

Release Data :

2012-08-29

Compound :

mol_id	molecule	chains	synonym
1	Thioesterase superfamily member 4	A,B	Carboxyl-terminal modulator protein
	ec: 3.1.2.20 fragment: residues 40-240

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CTMP, THEM4 expression_system_strain: BL21codon plus(DE3) RIL expression_system_vector_type: plasmid expression_system_plasmid: pET-23a

Authors :

Lim, K., Pathak, M.C., Herzberg, O.

Keywords :

hotdog fold, acyl CoA hydrolase; akt c-terminal modulating protein, acyl-CoA, hydrolase-hydrolase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.3 Å )

Citation :

Correlation of structure and function in the human hotdog-fold enzyme hTHEM4.

Zhao, H.,Lim, K.,Choudry, A. et al.
(2012) Biochemistry 51 : 6490 - 6492

The Akt C-Terminal modulator protein is an acyl-CoA thioesterase of the hotdog-fold family

Zhao, H.,Martin, B.,Bisoffi, M. et al.
(2009) Biochemistry 48 : 5507 - 5509

Chain :

A, B

UniProt :

Q5T1C6 (THEM4_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate	3.1.2.2	PubMed:19453107, PubMed:22871024
H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate	left-to-right	PubMed:19453107
H2O + octanoyl-CoA = CoA + H(+) + octanoate	-	PubMed:19453107
H2O + octanoyl-CoA = CoA + H(+) + octanoate	left-to-right	PubMed:19453107
decanoyl-CoA + H2O = CoA + decanoate + H(+)	-	PubMed:19453107
decanoyl-CoA + H2O = CoA + decanoate + H(+)	left-to-right	PubMed:19453107
dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+)	-	PubMed:19453107
dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+)	left-to-right	PubMed:19453107
H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate	-	PubMed:19453107
H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate	left-to-right	PubMed:19453107
(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)	-	PubMed:19453107
	left-to-right	PubMed:19453107
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)- eicosatetraenoate + CoA + H(+)	-	PubMed:19453107
	left-to-right	PubMed:19453107

PDB ID: 4GAH