Brand  (β version)

PDB ID: 4G9P

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Ligands
Code Name Style Show Link
CDI 2c-methyl-D-erythritol 2,4-cyclodiphosphate PoSSuM
CL Chloride ion PoSSuM
K Potassium ion PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
SF4 Iron/sulfur cluster PoSSuM
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Structure summary

Code : 4G9P   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of the GcpE-MEcPP (IspG) complex from Thermus thermophilus
Release Data : 2012-09-26
Compound :
mol_id molecule chains synonym
1 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase A 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
ec: 1.17.7.1
Source :
mol_id organism_scientific expression_system
1 Thermus thermophilus  (taxid:262724) Escherichia coli  (taxid:562)
strain: HB27 / ATCC BAA-163 / DSM 7039
gene: gcpE, ispG, TT_C1677
expression_system_vector_type: plasmid
expression_system_plasmid: PQETTGCPE
Authors : Rekittke, I., Jomaa, H., Ermler, U.
Keywords : Oxidoreductase, isoprenoid biosynthesis, non mevalonate pathway, iron-sulphur-cluster, TIM-barrel, MEcPP
Exp. method : X-RAY DIFFRACTION ( 1.550 Å )
Citation :

Structure of the GcpE (IspG)-MEcPP complex from Thermus thermophilus.

Rekittke, I.,Jomaa, H.,Ermler, U.
(2012)  Febs Lett.  586 : 3452 - 3457

PubMed: 22967895
DOI: 10.1016/j.febslet.2012.07.070

Reaction

Chain : A
UniProt : Q72H18 (ISPG_THET2)
Reaction: EC: Evidence:
Physiological Direction:
(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin] 1.17.7.3 HAMAP-Rule:MF_00159
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