Het-PDB Navi2 (PDB: 4G90)

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Ligands
Code	Name		Style	Show	Link
0G0	1-{[1-(alpha-L-arabinofuranosyl)-1h-1,2,3-triazol-4-yl]methyl}-5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidine				PoSSuM

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Download interaction data: 4G90

Code :

4G90 PDBj RCSB PDB PDBe

Header :

Hydrolase/Hydrolase Inhibitor

Title :

Crystal structure of Ribonuclease A in complex with 5e

Release Data :

2012-11-21

Compound :

mol_id	molecule	chains	synonym
1	Ribonuclease pancreatic	A,B	RNase 1, RNase A
	ec: 3.1.27.5

Source :

mol_id	organism_scientific	organism_common
1	Bos taurus (taxid:9913)	Bovine,cow,domestic cattle,domestic cow
	tissue: pancreas

Authors :

Chatzileontiadou, D.S.M., Kantsadi, A.L., Leonidas, D.D.

Keywords :

nuclease, Hydrolase-Hydrolase Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.

Parmenopoulou, V.,Chatzileontiadou, D.S.,Manta, S. et al.
(2012) Bioorg.Med.Chem. 20 : 7184 - 7193

Chain :

A, B

UniProt :

P61823 (RNAS1_BOVIN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].	4.6.1.18	-
	-	-
an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].	4.6.1.18	-
	-	-

PDB ID: 4G90