Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0FT 1-{[1-(alpha-L-arabinofuranosyl)-1h-1,2,3-triazol-4-yl]methyl}-5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine
Code : 4G8Y
Header : Hydrolase/Hydrolase Inhibitor
Title : Crystal structure of Ribonuclease A in complex with 5b
Release Data : 2012-11-21
Compound :
mol_id molecule chains synonym
1 Ribonuclease pancreatic A,B RNase 1, RNase A
ec: 3.1.27.5
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow
tissue: pancreas
Authors : Chatzileontiadou, D.S.M., Kantsadi, A.L., Leonidas, D.D.
Keywords : nuclease, Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.8 Å )
Citation :

Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.

Parmenopoulou, V.,Chatzileontiadou, D.S.,Manta, S.  et al.
(2012)  Bioorg.Med.Chem.  20 : 7184 - 7193

PubMed: 23122937
DOI: 10.1016/j.bmc.2012.09.067

Chain : A, B
UniProt : P61823 (RNAS1_BOVIN)
Reaction : Endonucleolytic cleavage to nucleoside 3'- phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.