Het-PDB Navi2 (PDB: 4G8R)

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Download interaction data: 4G8R

Code :

4G8R PDBj RCSB PDB PDBe

Header :

BLOOD CLOTTING/INHIBITOR

Title :

Crystal Structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1

Release Data :

2013-12-25

Compound :

mol_id	molecule	chains	synonym
1	Plasminogen activator inhibitor-1	A,B	PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1
	fragment: UNP residues 28-402

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: PAI-1, PAI1, PLANH1, SERPINE1 expression_system_strain: BL21(DE3) PLYSS expression_system_vector_type: CRE/LOXP

Authors :

Stuckey, J.A., Lawrence, D.A., Li, S.-H.

Keywords :

SERPIN, PAI-1, INHIBITOR, BLOOD CLOTTING, BLOOD CLOTTING-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.19 Å )

Citation :

Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1.

Li, S.H.,Reinke, A.A.,Sanders, K.L. et al.
(2013) Proc.Natl.Acad.Sci.USA 110 : E4941 - E4949

PDB ID: 4G8R