PDB ID: 4G34
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Structure summary
Code : | 4G34 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | Crystal Structure of GSK6924 Bound to PERK (R587-R1092, delete A660-T867) at 2.70 A Resolution | ||||||||||||
Release Data : | 2012-08-08 | ||||||||||||
Compound : |
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Source : |
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Authors : | Gampe, R.T., Axten, J.M. | ||||||||||||
Keywords : | deletion mutant, catalytic domain, synthetic inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.70 Å ) | ||||||||||||
Citation : |
Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK).
Axten, J.M.,Medina, J.R.,Feng, Y.
et al.
PubMed: 22827572 |
Reaction
Chain : | A | ||||||||||||
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UniProt : | Q9NZJ5 (E2AK3_HUMAN) | ||||||||||||
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