PDB ID: 4G2J
Hetero Atom Contents
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ZN | Zinc ion | PoSSuM | |||
MG | Magnesium ion | PoSSuM | |||
0WF | 1-cyclopentyl-6-[(1r)-1-(3-phenoxyazetidin-1-yl)ethyl]-1,5-dihydro-4h-pyrazolo[3,4-D]pyrimidin-4-one | PoSSuM |
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Download interaction data: 4G2J
Structure summary
Code : | 4G2J PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Human pde9 in complex with selective compound | ||||||||||||
Release Data : | 2013-05-29 | ||||||||||||
Compound : |
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Authors : | Liu, S. | ||||||||||||
Keywords : | phosphodiesterase, inhibitors, cGMP->GMP, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.40 Å ) | ||||||||||||
Citation : |
Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.
Claffey, M.M.,Helal, C.J.,Verhoest, P.R.
et al.
PubMed: 23025719 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | O76083 (PDE9A_HUMAN) | ||||||||
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