Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
ZN Zinc ion
MG Magnesium ion
0WF 1-cyclopentyl-6-[(1r)-1-(3-phenoxyazetidin-1-yl)ethyl]-1,5-dihydro-4h-pyrazolo[3,4-D]pyrimidin-4-one
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 4G2J   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Human pde9 in complex with selective compound
Release Data : 2013-05-29
Compound :
mol_id molecule chains
1 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A A,B
ec: 3.1.4.35
fragment: UNP Residues 242-566
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
gene: PDE9A
Authors : Liu, S.
Keywords : phosphodiesterase, inhibitors, cGMP->GMP, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.

Claffey, M.M.,Helal, C.J.,Verhoest, P.R.  et al.
(2012)  J.Med.Chem.  55 : 9055 - 9068

PubMed: 23025719
DOI: 10.1021/jm3009635

Chain : A, B
UniProt : O76083 (PDE9A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
3',5'-cyclic GMP + H2O = GMP + H(+) 3.1.4.35 PubMed:18757755, PubMed:21483814, PubMed:9624146
-