Het-PDB Navi2 (PDB: 4G2F)

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Ligands
Code	Name		Style	Show	Link
C07	1-amino-5-(5-hydroxy-2-methylphenyl)-7,8,9,10-tetrahydropyrimido[4,5-C]isoquinolin-6(5h)-one				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4G2F

Code :

4G2F PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Human EphA3 kinase domain in complex with compound 7

Release Data :

2012-10-24

Compound :

mol_id	molecule	chains
1	EPH receptor A3	A
	ec: 2.7.10.1 fragment: Kinase domain, UNP Residues 606-947

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: EPHA3 expression_system_strain: Bl21(de3) expression_system_vector_type: PLASMID expression_system_plasmid: p28-LIC-Thrombin

Authors :

Dong, J., Caflisch, A.

Keywords :

RECEPTOR TYROSINE KINASE, ATP Binding, Phosphorylation, Membrane, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.699 Å )

Citation :

Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics.

Zhao, H.,Dong, J.,Lafleur, K. et al.
(2012) ACS MED.CHEM.LETT. 3 : 834 - 838

Chain :

UniProt :

Q6P4R6 (Q6P4R6_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	ARBA:ARBA00001171
	-	ARBA:ARBA00001171

PDB ID: 4G2F