Het-PDB Navi2 (PDB: 4G1Y)

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Ligands
Code	Name		Style	Show	Link
0VO	(4e,6z)-7-(3-{[3,4-bis(hydroxymethyl)benzyl]oxy}phenyl)-3-ethylnona-4,6-dien-3-ol				PoSSuM

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Download interaction data: 4G1Y

Code :

4G1Y PDBj RCSB PDB PDBe

Header :

transcription/transcription inhibitor

Title :

Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor

Release Data :

2012-09-26

Compound :

mol_id	molecule	chains	synonym
1	Vitamin D3 receptor A	A	VDR-A, 1,25-dihydroxyvitamin D3 receptor A, Nuclear receptor subfamily 1 group I member 1-A
	fragment: unp residues 156-453

mol_id	molecule	chains	synonym
2	Nuclear receptor coactivator 1	B	NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1
	ec: 2.3.1.48 fragment: unp residues 686-700

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Danio rerio (taxid:7955)	Leopard danio,zebra danio,zebra fish	Escherichia coli (taxid:562)
	gene: vdra, nr1i1a, vdr expression_system_strain: BL21DE3 expression_system_plasmid: pET28

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes other_details: from human sequence

Authors :

Ciesielski, F., Sato, Y., Moras, D., Rochel, N.

Keywords :

VDR, transcription regulation, nuclear receptor, alpha helical sandwich, ligand, DNA, phosphorylation, nucleus, transcription-transcription inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.85 Å )

Citation :

Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor.

Ciesielski, F.,Sato, Y.,Chebaro, Y. et al.
(2012) J.Med.Chem. 55 : 8440 - 8449

PubMed: 22957834
DOI: 10.1021/jm300858s

Chain :	A
UniProt :	Q9PTN2 (VDRA_DANRE)
Reaction :	-

PDB ID: 4G1Y

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Structure summary

Reaction