Brand  (β version)

PDB ID: 4G1F

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Ligands
Code Name Style Show Link
0WG 7-amino-6-(aminomethyl)-5-(2-bromophenyl)-1,3-dimethylpyrido[2,3-D]pyrimidine-2,4(1h,3h)-dione PoSSuM
Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
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Structure summary

Code : 4G1F   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal Structure of human Dipeptidyl Peptidase IV in complex with a pyridopyrimidinedione analogue
Release Data : 2013-02-27
Compound :
mol_id molecule chains synonym
1 Dipeptidyl peptidase 4 A,B,C,D ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form
ec: 3.4.14.5
fragment: UNP residues 39-766
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: ADCP2, CD26, DPP4
Authors : Skene, R.J., Gwaltney, S.L.
Keywords : protease, 8-bladed beta-propeller domain, Aminopeptidase, Cell membrane, Glycoprotein, Hydrolase, Secreted, Serine protease, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors.

Lam, B.,Zhang, Z.,Stafford, J.A.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 6628 - 6631

PubMed: 23025999
DOI: 10.1016/j.bmcl.2012.08.110

Reaction

Chain : A, B, C, D
UniProt : P27487 (DPP4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. 3.4.14.5 PROSITE- ProRule:PRU10084, PubMed:10593948
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