Brand  (β version)

PDB ID: 4FYO

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Ligands
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0VF 4-{[(3s)-1-{7-[(3,4-dimethoxyphenyl)amino][1,3]thiazolo[5,4-D]pyrimidin-5-yl}pyrrolidin-3-yl]carbamoyl}benzoic acid PoSSuM
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Structure summary

Code : 4FYO   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of spleen tyrosine kinase complexed with N-{(S)-1-[7-(3,4-Dimethoxy-phenylamino)-thiazolo[5,4-D]pyrimidin-5-yl]-pyrrolidin-3-yl}-terephthalamic acid
Release Data : 2013-01-30
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase SYK A Spleen tyrosine kinase, p72-Syk
ec: 2.7.10.2
fragment: RESIDUES 356-635, PROTEIN KINASE DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: SYK
expression_system_common: Fall armyworm
expression_system_strain: SF9
expression_system_vector_type: BACULOVIRUS
Authors : Kuglstatter, A., Slade, M.
Keywords : kinase inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.40 Å )
Citation :

Rational design of highly selective spleen tyrosine kinase inhibitors.

Lucas, M.C.,Goldstein, D.M.,Hermann, J.C.  et al.
(2012)  J.Med.Chem.  55 : 10414 - 10423

PubMed: 23151054
DOI: 10.1021/jm301367c

Reaction

Chain : A
UniProt : P43405 (KSYK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301
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