Het-PDB Navi2 (PDB: 4FXY)

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Ligands
Code	Name		Style	Show	Link
0W2	1-{(2s)-1-[(3r)-3-(2-chlorophenyl)-2-(2-fluorophenyl)pyrazolidin-1-yl]-1-oxopropan-2-yl}-3-[(1r,3s,5r,7r)-tricyclo[3.3.1.1~3,7~]dec-2-yl]urea				PoSSuM
ZN	Zinc ion				PoSSuM

Non-standard Residues
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Download interaction data: 4FXY

Code :

4FXY PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal structure of rat neurolysin with bound pyrazolidin inhibitor

Release Data :

2013-11-13

Compound :

mol_id	molecule	chains	synonym
1	Neurolysin, mitochondrial	P,Q	Microsomal endopeptidase, MEP, Mitochondrial oligopeptidase M, Neurotensin endopeptidase
	ec: 3.4.24.16 mutation: H160A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Rat	Escherichia coli (taxid:562)
	gene: Nln expression_system_strain: TOP 10 expression_system_vector_type: plasmid expression_system_plasmid: pBAD/His C

Authors :

Rodgers, D.W., Hines, C.S.

Keywords :

hydrolase, endopeptidase, zinc metallopeptidase, neuropeptidase, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.800 Å )

Citation :

Allosteric inhibition of the neuropeptidase neurolysin.

Hines, C.S.,Ray, K.,Schmidt, J.J. et al.
(2014) J.Biol.Chem. 289 : 35605 - 35619

Chain :

P, Q

UniProt :

P42676 (NEUL_RAT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Preferential cleavage in neurotensin: 10-Pro-\|-Tyr-11.	3.4.24.16	PubMed:12500972, PubMed:7836437
Preferential cleavage in neurotensin: 10-Pro-\|-Tyr-11.	-	PubMed:12500972, PubMed:7836437

PDB ID: 4FXY