Brand  (β version)

PDB ID: 4FVT

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Ligands
Code Name Style Show Link
CNA Carba-nicotinamide-adenine-dinucleotide PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
ALY N(6)-acetyllysine
NLE Norleucine
Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 4FVT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Human SIRT3 bound to Ac-ACS peptide and Carba-NAD
Release Data : 2012-08-15
Compound :
mol_id molecule chains synonym
1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial A hSIRT3, Regulatory protein SIR2 homolog 3, SIR2-like protein 3
ec: 3.5.1.-
fragment: UNP residues 122-395
mol_id molecule chains
2 Acetylated ACS2 peptide B
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
mol_id organism_scientific
2
synthetic: yes
other_details: Synthetic Ac-ACS2 peptide
Authors : Dai, H.
Keywords : Sirtuin, Carba-NAD, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.47 Å )
Citation :

Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5.

Szczepankiewicz, B.G.,Dai, H.,Koppetsch, K.J.  et al.
(2012)  J.Org.Chem.  77 : 7319 - 7329

PubMed: 22849721
DOI: 10.1021/jo301067e

Reaction

Chain : A
UniProt : Q9NTG7 (SIR3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide 2.3.1.286 PROSITE-ProRule:PRU00236, PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:19535340, PubMed:24121500, PubMed:23283301
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