Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0V4 (4r,5r,6r,6as,9s,9ae,10ar)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,D][8]annulen-4-yl alpha-D-glucopyranoside
MG Magnesium ion
Modified Residues
Code Name Link
CSO S-hydroxycysteine
SEP Phosphoserine
Code : 4FR3   PDBj   RCSB PDB   PDBe
Header : PEPTIDE BINDING PROTEIN/TOXIN
Title : Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H
Release Data : 2013-05-08
Compound :
mol_id molecule chains synonym
1 14-3-3 protein sigma A Epithelial cell marker protein 1, Stratifin
mol_id molecule chains
2 TASK-3 peptide P
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HME1, SFN
expression_system_strain: Rosetta DE3
expression_system_vector_type: Plasmid
expression_system_plasmid: pPROEX HTB
mol_id organism_scientific
2 HOMO SAPIENS  (taxid:9606)
synthetic: yes
other_details: Synthetic peptide
Authors : Ottmann, C., Anders, C., Schumacher, B.
Keywords : Nucleus, PEPTIDE BINDING PROTEIN-TOXIN complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface.

Anders, C.,Higuchi, Y.,Koschinsky, K.  et al.
(2013)  Chem.Biol.  20 : 583 - 593

PubMed: 23601647
DOI: 10.1016/j.chembiol.2013.03.015

Chain : A
UniProt : P31947 (1433S_HUMAN)
Reaction : -