Het-PDB Navi2 (PDB: 4FR1)

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Ligands
Code	Name		Style	Show	Link
0V2	6-amino-4-[2-({[trans-4-(biphenyl-4-ylethynyl)cyclohexyl]methyl}amino)ethyl]-2-(methylamino)-1,7-dihydro-8h-imidazo[4,5-G]quinazolin-8-one				PoSSuM
ZN	Zinc ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4FR1

Code :

4FR1 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE inhibitor

Title :

tRNA-Guanine Transglycosylase cocrystallized with alkine-substituted lin-benzoguanine ligand

Release Data :

2013-07-24

Compound :

mol_id	molecule	chains	synonym
1	Queuine tRNA-ribosyltransferase	A	Guanine insertion enzyme, tRNA-guanine transglycosylase
	ec: 2.4.2.29

Source :

mol_id	organism_scientific	expression_system
1	Zymomonas mobilis subsp. mobilis (taxid:264203)	Escherichia coli (taxid:469008)
	strain: ATCC 31821 / ZM4 / CP4 gene: tgt, ZMO0363 expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_plasmid: PET9D

Authors :

Immekus, F., Klebe, G.

Keywords :

TIM BARREL, GLYCOSYLTRANSFERASE, QUEUOSINE, BIOSYNTHESIS, TRANSFERASE, TRNA PROCESSING, TRNA, TRANSFERASE-TRANSFERASE inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.74 Å )

Citation :

Studies on TGT homodimer interface

Immekus, F.,Barandun, L.J.,Betz, M. et al.
To be Published

Chain :

UniProt :

P28720 (TGT_ZYMMO)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7- aminomethyl-7-carbaguanosine(34) in tRNA + guanine	2.4.2.29	HAMAP- Rule:MF_00168, PubMed:7665516
	-	HAMAP- Rule:MF_00168, PubMed:7665516

PDB ID: 4FR1