Brand  (β version)

PDB ID: 4FPS

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Ligands
Code Name Style Show Link
0UX 6-amino-2-(methylamino)-4-(2-{[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylmethyl]amino}ethyl)-1,7-dihydro-8h-imidazo[4,5-G]quinazolin-8-one PoSSuM
GOL Glycerol PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4FPS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE inhibitor
Title : tRNA-Guanine Transglycosylase in complex with adamantyl-substituted lin-benzoguanine ligand
Release Data : 2013-07-24
Compound :
mol_id molecule chains synonym
1 Queuine tRNA-ribosyltransferase A Guanine insertion enzyme, tRNA-guanine transglycosylase
ec: 2.4.2.29
Source :
mol_id organism_scientific expression_system
1 Zymomonas mobilis subsp. mobilis  (taxid:264203) Escherichia coli  (taxid:469008)
strain: ATCC 31821 / ZM4 / CP4
gene: tgt, ZMO0363
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET9D
Authors : Immekus, F., Klebe, G.
Keywords : TIM BARREL, GLYCOSYLTRANSFERASE, QUEUOSINE, BIOSYNTHESIS, TRANSFERASE, TRNA PROCESSING, TRNA, TRANSFERASE-TRANSFERASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.45 Å )
Citation :

Studies on TGT homodimer interface

Immekus, F.,Barandun, L.J.,Betz, M.  et al.
To be Published 

Reaction

Chain : A
UniProt : P28720 (TGT_ZYMMO)
Reaction: EC: Evidence:
Physiological Direction:
7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7- aminomethyl-7-carbaguanosine(34) in tRNA + guanine 2.4.2.29 HAMAP-Rule:MF_00168, PubMed:7665516
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Cofactor: Evidence: Note:
Zn(2+) ECO:0000255 | HAMAP-Rule:MF_00168
ECO:0000269 | PubMed:10413112
ECO:0000269 | PubMed:11178905
ECO:0000269 | PubMed:11921407
ECO:0000269 | PubMed:12646024
ECO:0000269 | PubMed:12909636
ECO:0000269 | PubMed:12949492
ECO:0000269 | PubMed:14523925
ECO:0000269 | PubMed:19627989
ECO:0000269 | PubMed:8654383
ECO:0000269 | PubMed:8961936
Binds 1 zinc ion per subunit.