Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0V7 2-[(3-fluorobenzyl)amino]ethanesulfonic acid
DMS Dimethyl sulfoxide
Code : 4FPH
Header : HYDROLASE/INHIBITOR
Title : Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Fluorobenzyl)ammonio]ethanesulfonate
Release Data : 2012-10-31
Compound :
mol_id molecule chains synonym
1 Sialidase B A Neuraminidase B
ec: 3.2.1.18
Source :
mol_id organism_scientific expression_system
1 Streptococcus pneumoniae  (taxid:1313) Escherichia coli  (taxid:469008)
strain: TIGR4
gene: nanB, SP_1687
expression_system_strain: Bl21(de3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET23b
Authors : Brear, P.
Keywords : hydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, HYDROLASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.9380 Å )
Citation :

Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.

Brear, P.,Telford, J.,Taylor, G.L.  et al.
(2012)  Chembiochem  13 : 2374 - 2383

PubMed: 23070966
DOI: 10.1002/cbic.201200433

Chain : A
UniProt : Q54727 (NANB_STRPN)
Reaction : Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.