Het-PDB Navi2 (PDB: 4FPH)

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Ligands
Code	Name		Style	Show	Link
0V7	2-[(3-fluorobenzyl)amino]ethanesulfonic acid				PoSSuM
DMS	Dimethyl sulfoxide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4FPH

Code :

4FPH PDBj RCSB PDB PDBe

Header :

HYDROLASE/INHIBITOR

Title :

Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Fluorobenzyl)ammonio]ethanesulfonate

Release Data :

2012-10-31

Compound :

mol_id	molecule	chains	synonym
1	Sialidase B	A	Neuraminidase B
	ec: 3.2.1.18

Source :

mol_id	organism_scientific	expression_system
1	Streptococcus pneumoniae (taxid:1313)	Escherichia coli (taxid:469008)
	strain: TIGR4 gene: nanB, SP_1687 expression_system_strain: Bl21(de3) expression_system_vector_type: plasmid expression_system_plasmid: pET23b

Authors :

Brear, P.

Keywords :

hydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, HYDROLASE-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.9380 Å )

Citation :

Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.

Brear, P.,Telford, J.,Taylor, G.L. et al.
(2012) Chembiochem 13 : 2374 - 2383

Chain :

UniProt :

Q54727 (NANB_STRPN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha- (2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.	3.2.1.18	-
	-	-

PDB ID: 4FPH