Brand  (β version)

color scheme of protein:


interaction residue:


Code Name Link
0US N-{1-[cis-4-(hydroxymethyl)cyclohexyl]-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl}-3-(prop-2-en-1-ylsulfamoyl)benzamide
Code : 4FOB   PDBj   RCSB PDB   PDBe
Header : Transferase/Inhibitor
Title : Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 1
Release Data : 2012-07-11
Compound :
mol_id molecule chains synonym
1 ALK tyrosine kinase receptor A Anaplastic lymphoma kinase
fragment: Kinase domain, unp residues 1058-1410
mutation: C1097S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: ALK
expression_system_vector_type: baculovirus
Authors : Whittington, D.A., Epstein, L.F., Chen, H.
Keywords : receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, CD246, phosphotransferase, NPM-ALK, EML4-ALK, in situ proteolysis, Transferase-Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.9000 Å )
Citation :

The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer.

Lewis, R.T.,Bode, C.M.,Choquette, D.M.  et al.
(2012)  J.Med.Chem.  55 : 6523 - 6540

PubMed: 22734674
DOI: 10.1021/jm3005866

Chain : A
UniProt : Q9UM73 (ALK_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.