Brand  (β version)

PDB ID: 4FLP

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Ligands
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JQ1 (6s)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium PoSSuM
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Structure summary

Code : 4FLP   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION REGULATOR/INHIBITOR
Title : Crystal Structure of the first bromodomain of human BRDT in complex with the inhibitor JQ1
Release Data : 2012-07-11
Compound :
mol_id molecule chains synonym
1 Bromodomain testis-specific protein A,B Cancer/testis antigen 9, CT9, RING3-like protein
fragment: first bromodomain (UNP residues 21-137)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BRDT
expression_system_strain: BL21(DE3)-R3
expression_system_vector_type: Plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., Canning, P., Muniz, J., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Bradner, J., Knapp, S., Structural Genomics Consortium (SGC)
Keywords : BRDT, bromodomain containing protein testis specific, Nucleus, Transcription, Transcription regulation, Structural Genomics Consortium, SGC, Bromodomain, TRANSCRIPTION REGULATOR-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.23 Å )
Citation :

Small-Molecule Inhibition of BRDT for Male Contraception.

Matzuk, M.M.,McKeown, M.R.,Filippakopoulos, P.  et al.
(2012)  Cell(Cambridge,Mass.)  150 : 673 - 684

PubMed: 22901802
DOI: 10.1016/j.cell.2012.06.045

Reaction

Chain : A, B
UniProt : Q58F21 (BRDT_HUMAN)
Reaction : -