Brand  (β version)

PDB ID: 4FHI

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Ligands
Code Name Style Show Link
0S4 N-hydroxy-2-{4-[3-(4-{[(2r)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}acetamide PoSSuM
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Structure summary

Code : 4FHI   PDBj   RCSB PDB   PDBe
Header : Transcription/protein binding/inhibitor
Title : Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition
Release Data : 2012-09-19
Compound :
mol_id molecule chains
1 Vitamin Nuclear Receptor A
mol_id molecule chains
2 SRC-1 B
Source :
mol_id organism_scientific expression_system
1 Danio Rerio  (taxid:7955) Escherichia coli  (taxid:562)
mol_id organism_scientific
2 HOMO SAPIENS  (taxid:9606)
synthetic: yes
Authors : Fischer, J., Wang, T.T., Kaldre, D., Rochel, N., Moras, D., White, J.H., Gleason, J.L.
Keywords : ligand binding domain Alpha helical sandwich, alpha helical sandwich, transcription factor, DNA coregulators, phosphorylation, nucleus, Transcription-protein binding-inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Synthetically accessible non-secosteroidal hybrid molecules combining vitamin d receptor agonism and histone deacetylase inhibition.

Fischer, J.,Wang, T.T.,Kaldre, D.  et al.
(2012)  Chem.Biol.  19 : 963 - 971

PubMed: 22921063
DOI: 10.1016/j.chembiol.2012.05.024