Brand  (β version)

PDB ID: 4FHH

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Ligands
Code Name Style Show Link
0U3 N-hydroxy-2-{4-[3-(4-{[(2s)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}acetamide PoSSuM
Non-standard Residues
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Structure summary

Code : 4FHH   PDBj   RCSB PDB   PDBe
Header : Transcription/protein binding/inhibitor
Title : Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition
Release Data : 2012-09-19
Compound :
mol_id molecule chains synonym
1 Vitamin D3 receptor A A VDR-A, 1,25-dihydroxyvitamin D3 receptor A, Nuclear receptor subfamily 1 group I member 1-A
fragment: UNP RESIDUES 156-453
mol_id molecule chains synonym
2 Nuclear receptor coactivator 2 B NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2
fragment: UNP RESIDUES 686-698
Source :
mol_id organism_scientific organism_common expression_system
1 Danio rerio  (taxid:7955) Leopard danio,zebra danio,zebra fish Escherichia coli  (taxid:562)
gene: vdra, nr1i1a, vdr
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
other_details: This sequence occurs naturally in humans.
Authors : Fischer, J., Wang, T.T., Kaldre, D., Rochel, N., Moras, D., White, J.H., Gleason, J.L.
Keywords : Ligand binding domain, apha helical sandwich, alpha helical sandwich, transcription factor, ADN Coregulators, phosphorylation and HDAC inhibitor, nucleus, Transcription-protein binding-inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.33 Å )
Citation :

Synthetically accessible non-secosteroidal hybrid molecules combining vitamin d receptor agonism and histone deacetylase inhibition.

Fischer, J.,Wang, T.T.,Kaldre, D.  et al.
(2012)  Chem.Biol.  19 : 963 - 971

PubMed: 22921063
DOI: 10.1016/j.chembiol.2012.05.024

Reaction

Chain : A
UniProt : Q9PTN2 (VDRA_DANRE)
Reaction : -
Chain : B
UniProt : Q15596 (NCOA2_HUMAN)
Reaction : -