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Ligands
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0W3 (4r,6s,8s,12r,14r,16z,18r,19r,20s,21s)-19,21-dihydroxy-22-{(2s,2'R,5s,5'S)-5'-[(1r)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9,11-dioxodocos-16-enoic acid
Non-standard Residues
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Code : 4FGY   PDBj   RCSB PDB   PDBe
Header : Transcription/Transferase/Antibiotic
Title : Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity
Release Data : 2013-03-20
Compound :
mol_id molecule chains synonym
1 Peroxisome proliferator-activated receptor gamma A PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
fragment: LIGAND BINDING DOMAIN, UNP RESIDUES 235-504
mol_id molecule chains synonym
2 Nuclear receptor coactivator 1 B NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1
ec: 2.3.1.48
fragment: UNP RESIDUES 686-696
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: NR1C3, PPARG
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET24a
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Wang, R., Li, Y.
Keywords : PPAR LBD, nuclear receptor fold, ligand binding, gene transcription, Transcription-Transferase-Antibiotic complex
Exp. method : X-RAY DIFFRACTION ( 2.84 Å )
Citation :

Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor Gamma (PPAR-gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes.

Zheng, W.,Feng, X.,Qiu, L.  et al.
(2013)  Diabetologia  56 : 401 - 411

PubMed: 23178929
DOI: 10.1007/s00125-012-2777-9

Chain : A
UniProt : P37231 (PPARG_HUMAN)
Reaction : -
Chain : B
UniProt : Q15788 (NCOA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] 2.3.1.48 -
-