PDB ID: 4FGY
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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0W3 | (4r,6s,8s,12r,14r,16z,18r,19r,20s,21s)-19,21-dihydroxy-22-{(2s,2'R,5s,5'S)-5'-[(1r)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9,11-dioxodocos-16-enoic acid | PoSSuM |
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Download interaction data: 4FGY
Structure summary
Code : | 4FGY PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | Transcription/Transferase/Antibiotic | ||||||||||||||||||||||||
Title : | Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity | ||||||||||||||||||||||||
Release Data : | 2013-03-20 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Wang, R., Li, Y. | ||||||||||||||||||||||||
Keywords : | PPAR LBD, nuclear receptor fold, ligand binding, gene transcription, Transcription-Transferase-Antibiotic complex | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.84 Å ) | ||||||||||||||||||||||||
Citation : |
Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor Gamma (PPAR-gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes.
Zheng, W.,Feng, X.,Qiu, L.
et al.
PubMed: 23178929 |
Reaction
Chain : | A |
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UniProt : | P37231 (PPARG_HUMAN) |
Reaction : | - |
Chain : | B | ||||||||
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UniProt : | Q15788 (NCOA1_HUMAN) | ||||||||
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