Brand  (β version)

PDB ID: 4FGK

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Ligands
Code Name Style Show Link
0TX (4s)-N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4FGK   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor
Title : Oxidized quinone reductase 2 in complex with chloroquine
Release Data : 2013-03-13
Compound :
mol_id molecule chains synonym
1 Ribosyldihydronicotinamide dehydrogenase [quinone] A,B NRH dehydrogenase [quinone] 2, NRH:quinone oxidoreductase 2, Quinone reductase 2, QR2
ec: 1.10.99.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: NMOR2, NQO2
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pProNQO2
Authors : Leung, K.K., Shilton, B.H.
Keywords : chloroquine, FMN reductase superfamily (conserved domain database), metallo-flavoprotein, Rossmann fold, two-electron reduction of quinones to hydroquinones, FAD binding, Zn binding, cytosol, OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.4010 Å )
Citation :

Crystal structures of quinone reductase 2 bound to antimalarial drugs reveal conformational change upon reduction

Leung, K.K.,Shilton, B.H.
(2013)  J.Biol.Chem. 

Reaction

Chain : A, B
UniProt : P16083 (NQO2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol 1.10.5.1 PubMed:18579530
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Cofactor: Evidence: Note:
Zn(2+) - Binds 1 zinc ion per subunit.
FAD - Binds 1 zinc ion per subunit.