PDB ID: 4FEX
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Structure summary
Code : | 4FEX PDBj RCSB PDB PDBe | ||||||||||||
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Header : | transferase/transferase INHIBITOR | ||||||||||||
Title : | Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor tyrphostin AG1478 | ||||||||||||
Release Data : | 2012-06-20 | ||||||||||||
Compound : |
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Source : |
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Authors : | Stogios, P.J., Evdokimova, E., Wawrzak, Z., Minasov, G., Egorova, O., Di Leo, R., Shakya, T., Spanogiannopoulos, P., Wright, G.D., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID) | ||||||||||||
Keywords : | tyrphostin, 4-anilinoquinazoline, tyrphostin AG1478, AG1478, protein kinase inhibitor, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, NIAID, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, EUKARYOTIC PROTEIN KINASE-LIKE FOLD, ALPHA/BETA PROTEIN, TRANSFERASE, PHOSPHOTRANSFERASE, AMINOGLYCOSIDE PHOSPHOTRANSFERASE, ANTIBIOTIC RESISTANCE, AMINOGLYCOSIDES, KANAMYCIN, GTP, INTRACELLULAR, transferase-transferase INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.710 Å ) | ||||||||||||
Citation : |
Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Stogios, P.J.,Spanogiannopoulos, P.,Evdokimova, E.
et al.
PubMed: 23758273 |
Reaction
Chain : | A, B, C, D, E |
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UniProt : | B0VD92 |
Reaction : | - |