Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0T8 4-(cyclopentylamino)-N-[3-(2-oxopyrrolidin-1-yl)propyl]-2-{[2-(pyridin-4-yl)ethyl]amino}pyrimidine-5-carboxamide
Code : 4FEQ
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)
Release Data : 2013-03-13
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase receptor TYRO3 A Etk2/tyro3, TK19-2, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE
ec: 2.7.10.1
fragment: Kinase domain (UNP residues 485-800)
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: Tyro3, Dtk, Rse
expression_system_common: Fall armyworm
Authors : Ohren, J.F., Powell, N.A., Kohrt, J.T., Perrin, L.A.
Keywords : Protein kinase domain, Receptor Tyrosine Kinase, Gas6, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.

Powell, N.A.,Hoffman, J.K.,Ciske, F.L.  et al.
(2013)  Bioorg.Med.Chem.Lett.  23 : 1046 - 1050

PubMed: 23312472
DOI: 10.1016/j.bmcl.2012.12.013

Chain : A
UniProt : P55144 (TYRO3_MOUSE)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.