Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0T3 4-[(5r)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile
HEM Protoporphyrin ix containing Fe
Code : 4FDH
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : Structure of human aldosterone synthase, CYP11B2, in complex with fadrozole
Release Data : 2013-01-30
Compound :
mol_id molecule chains synonym
1 Cytochrome P450 11B2, mitochondrial A,B,C,D,E,F,G,H,I,J,K,L Aldosterone synthase, ALDOS, Aldosterone-synthesizing enzyme, CYPXIB2, Cytochrome P-450Aldo, Cytochrome P-450C18, Steroid 18-hydroxylase
ec: 1.14.15.4, 1.14.15.5
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: Aldosterone synthase, CYP11B2
expression_system_strain: DH5a
expression_system_vector_type: plasmid
expression_system_plasmid: pCW
Authors : Strushkevich, N., Shen, L., Tempel, W., Arrowsmith, C., Edwards, A., Usanov, S.A., Park, H.-W.
Keywords : cytochrome P450, CYP11B2, Aldosterone synthase, monooxygenase, heme protein, mineralocorticoid, inhibitor, mitochondria, membrane, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.71 Å )
Citation :

Structural insights into aldosterone synthase substrate specificity and targeted inhibition.

Strushkevich, N.,Gilep, A.A.,Shen, L.  et al.
(2013)  Mol.Endocrinol.  27 : 315 - 324

PubMed: 23322723
DOI: 10.1210/me.2012-1287

Chain : A, B, C, D, E, F, G, H, I, J, K, L
UniProt : P19099 (C11B2_HUMAN)
Reaction : A steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) = an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H(2)O.
Corticosterone + 2 reduced adrenodoxin + O(2) + 2 H(+) = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H(2)O.