Brand  (β version)

PDB ID: 4F9B

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Ligands
Code Name Style Show Link
0SY 2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-C]pyridin-4-one PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4F9B   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Human CDC7 kinase in complex with DBF4 and PHA767491
Release Data : 2012-10-31
Compound :
mol_id molecule chains synonym
1 Cell division cycle 7-related protein kinase A,C CDC7-related kinase, HsCdc7, huCdc7
ec: 2.7.11.1
mol_id molecule chains synonym
2 Protein DBF4 homolog A B,D Activator of S phase kinase, Chiffon homolog A, DBF4-type zinc finger-containing protein 1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CDC7, CDC7L1
expression_system_strain: Rosetta-2(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pRSF-Duet
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ASK, DBF4, DBF4A, ZDBF1
expression_system_strain: Rosetta-2(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pCDF-Duet
Authors : Hughes, S., Cherepanov, P.
Keywords : SER/THR PROTEIN KINASE, TRANSFERASE, PHOSPHORYLATION, CELL CYCLE, CELL DIVISION, MITOSIS, S PHASE, SERINE/THREONINE-PROTEIN KINASE, DBF4-dependent kinase, DDK, ATP-BINDING, NUCLEOTIDE-BINDING, ZINC-BINDING, NUCLEUS, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Crystal structure of human CDC7 kinase in complex with its activator DBF4.

Hughes, S.,Elustondo, F.,Di Fonzo, A.  et al.
(2012)  Nat.Struct.Mol.Biol.  19 : 1101 - 1107

PubMed: 23064647
DOI: 10.1038/nsmb.2404

Reaction

Chain : A, C
UniProt : O00311 (CDC7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:27401717
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:27401717
left-to-right
Chain : B, D
UniProt : Q9UBU7 (DBF4A_HUMAN)
Reaction : -