Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0SW N-(2-phenylethyl)quinazolin-4-amine
EDO 1,2-ethanediol
FMT Formic acid
Code : 4F7S
Header : TRANSFERASE/TRANSCRIPTION/INHIBITOR
Title : Crystal structure of human CDK8/CYCC in the DMG-in conformation
Release Data : 2013-05-01
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 8 A Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35
ec: 2.7.11.22, 2.7.11.23
fragment: UNP residues 1-403
mol_id molecule chains synonym
2 Cyclin-C B SRB11 homolog, hSRB11
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CDK8
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CCNC
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
Authors : Schneider, E.V., Boettcher, J., Huber, R., Maskos, K.
Keywords : protein kinase complex, Proteros, TRANSFERASE-TRANSCRIPTION-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Structure-kinetic relationship study of CDK8/CycC specific compounds.

Schneider, E.V.,Bottcher, J.,Huber, R.  et al.
(2013)  Proc.Natl.Acad.Sci.USA  110 : 8081 - 8086

PubMed: 23630251
DOI: 10.1073/pnas.1305378110

Chain : A
UniProt : P49336 (CDK8_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Chain : B
UniProt : P24863 (CCNC_HUMAN)
Reaction : -