Brand  (β version)

PDB ID: 4F4Q

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Ligands
Code Name Style Show Link
0SK 8-(hydroxyamino)-2-[(2s)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-6-(trifluoromethyl)-4h-1,3-benzothiazin-4-one PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Structure summary

Code : 4F4Q   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of M. smegmatis DprE1 in complex with FAD and covalently bound BTZ043
Release Data : 2012-09-05
Compound :
mol_id molecule chains
1 DprE1 A
fragment: DprE1
Source :
mol_id organism_scientific expression_system
1 Mycobacterium smegmatis  (taxid:246196) Escherichia coli  (taxid:562)
strain: ATCC 700084 / mc(2)155
gene: MSMEG_6382
Authors : Neres, J., Pojer, F., Molteni, E., Chiarelli, L., Riccardi, G., Mattevi, A., Cole, S.T., Binda, C.
Keywords : FAD domain, oxidase, BTZ043 covalently bound to Cys394, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.619 Å )
Citation :

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis.

Neres, J.,Pojer, F.,Molteni, E.  et al.
(2012)  Sci Transl Med  4 : 150ra121 - 150ra121

PubMed: 22956199
DOI: 10.1126/scitranslmed.3004395

Reaction

Chain : A
UniProt : A0R607 (DPRE1_MYCS2)
Reaction: EC: Evidence:
Physiological Direction:
FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D- ribofuranose = FADH2 + trans,octa-cis-decaprenylphospho-beta-D- erythro-pentofuranosid-2-ulose 1.1.98.3 PubMed:22188377
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