Het-PDB Navi2 (PDB: 4F3I)

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Ligands
Code	Name		Style	Show	Link
0S6	Methyl [(6s)-4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate				PoSSuM
EDO	1,2-ethanediol				PoSSuM

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Download interaction data: 4F3I

Code :

4F3I PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN/INHIBITOR

Title :

Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor

Release Data :

2012-09-12

Compound :

mol_id	molecule	chains	synonym
1	Bromodomain-containing protein 4	A	Protein HUNK1
	fragment: bromodomain 1 (UNP residues 44-168)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: BRD4, HUNK1

Authors :

Joshua, J., Zhou, M.-M., Plotnikov, A.N.

Keywords :

protein-inhibitor complex, acetyl-lysine binding, nucleus, SIGNALING PROTEIN-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.40 Å )

Citation :

Down-regulation of NF-{kappa}B Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition.

Zhang, G.,Liu, R.,Zhong, Y. et al.
(2012) J.Biol.Chem. 287 : 28840 - 28851

PDB ID: 4F3I