Brand  (β version)

PDB ID: 4F32

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
N32 2,4-dihydroxy-3-({3-[(2s,4as,8s,8ar)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2h-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid PoSSuM
Non-standard Residues
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CSU Cysteine-S-sulfonic acid
Glycosylation
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Structure summary

Code : 4F32   PDBj   RCSB PDB   PDBe
Header : Transferase/Antibiotic
Title : Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase II from Burkholderia vietnamiensis in complex with platencin
Release Data : 2012-05-23
Compound :
mol_id molecule chains
1 3-oxoacyl-[acyl-carrier-protein] synthase 2 A,B
ec: 2.3.1.179
mol_id molecule chains
2 Unknown peptide C
Source :
mol_id organism_scientific expression_system
1 Burkholderia vietnamiensis  (taxid:269482) Escherichia coli  (taxid:469008)
strain: G4/LMG 22486
gene: Bcep1808_4002
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: AVA0421
mol_id organism_scientific
2 Streptomyces platensis  (taxid:58346)
other_details: from a strain of S. platensis, MA7339, recovered from a soil sample collected in Minut II (Mallorca) in Spain, Proc Natl Acad Sci U S A. 2007 May 1;104(18):7612-6
Authors : Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Keywords : SSGCID, 3-oxoacyl-[acyl-carrier-protein] synthase II, platencin, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, Transferase-Antibiotic complex
Exp. method : X-RAY DIFFRACTION ( 1.9000 Å )
Citation :

Combining functional and structural genomics to sample the essential Burkholderia structome.

Baugh, L.,Gallagher, L.A.,Patrapuvich, R.  et al.
(2013)  Plos One  8 : e53851 - e53851

PubMed: 23382856
DOI: 10.1371/journal.pone.0053851

Reaction

Chain : A, B
UniProt : A4JL30 (A4JL30_BURVG)
Reaction: EC: Evidence:
Physiological Direction:
(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)- octadecenoyl-[ACP] + CO2 + holo-[ACP] 2.3.1.179 PIRNR:PIRNR000447
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a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP] - PIRNR:PIRNR000447
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