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Ligands
Code Name Style Show Link
CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile
ZN Zinc ion
Non-standard Residues
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Glycosylation
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Code : 4F1Y   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN/AGONIST
Title : CNQX bound to the ligand binding domain of GluA3
Release Data : 2012-05-16
Compound :
mol_id molecule chains synonym
1 Glutamate receptor 3 A,C GluR-3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3, Glutamate receptor ionotropic, AMPA 3, GluA3
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Glur3, Gria3, Gria3; GluA3
expression_system_strain: Origami B (DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET-22b(+)
Authors : Ahmed, A.H., Oswald, R.E.
Keywords : glutamate receptor, GluA3, GluR3, AMPA receptor, S1S2, LBD, neurotransmitter receptor, CNQX, TRANSPORT PROTEIN, TRANSPORT PROTEIN-AGONIST complex
Exp. method : X-RAY DIFFRACTION ( 1.790 Å )
Citation :

The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.

Holley, S.M.,Ahmed, A.H.,Srinivasan, J.  et al.
(2012)  Biochemistry  51 : 4015 - 4027

PubMed: 22512472
DOI: 10.1021/bi3001837

Chain : A, C
UniProt : P19492 (GRIA3_RAT)
Reaction : -