Brand  (β version)

PDB ID: 4F1L

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
0RY (2z)-4-[(3-carbamoylphenyl)amino]-4-oxobut-2-enoic acid PoSSuM
NO3 Nitrate ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4F1L   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase inhibitor
Title : Human Artd8 (Parp14, Bal2) - catalytic domain in complex with inhibitor A16(Z)
Release Data : 2012-09-05
Compound :
mol_id molecule chains synonym
1 Poly [ADP-ribose] polymerase 14 A,B,C,D PARP-14, B aggressive lymphoma protein 2
ec: 2.4.2.30
fragment: Catalytic domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: BAL2, KIAA1268, PARP14
expression_system_strain: BL21(DE3)R3 pRARE
expression_system_vector_type: PLASMID
expression_system_plasmid: pNIC28-Bsa4
Authors : Karlberg, T., Andersson, C.D., Lindgren, A., Spjut, S., Thorsell, A.G., Ekblad, T., Weigelt, J., Elofsson, M., Linusson, A., Schuler, H.
Keywords : NAD, ADP-RIBOSE, PARP14, BAL2, ARTD8, ARTD Transferase domain, ADP-ribosylation, Transferase-Transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening.

Andersson, C.D.,Karlberg, T.,Ekblad, T.  et al.
(2012)  J.Med.Chem.  55 : 7706 - 7718

PubMed: 22823910
DOI: 10.1021/jm300746d

Reaction

Chain : A, B, C, D
UniProt : Q460N5 (PAR14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide - PubMed:27796300
left-to-right