Brand  (β version)

PDB ID: 4F0E

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Ligands
Code Name Style Show Link
0RU 8-methyl-2-[(pyrimidin-2-ylsulfanyl)methyl]quinazolin-4(1h)-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4F0E   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Human ADP-RIBOSYLTRANSFERASE 7 (ARTD7/PARP15), CATALYTIC DOMAIN IN COMPLEX WITH STO1102
Release Data : 2012-09-05
Compound :
mol_id molecule chains synonym
1 Poly [ADP-ribose] polymerase 15 A,B,C,D PARP-15, B-aggressive lymphoma protein 3
ec: 2.4.2.30
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BAL3, PARP15
expression_system_strain: BL21(DE3)R3 pRARE
expression_system_vector_type: PLASMID
expression_system_plasmid: pNIC28-Bsa4
Authors : Karlberg, T., Andersson, C.D., Lindgren, A., Thorsell, A.G., Ekblad, T., Spjut, S., Weigelt, J., Elofsson, M., Linusson, A., Schuler, H.
Keywords : ARTD, PARP, POLY (ADP-RIBOSE) POLYMERASE, ADP-RIBOSE, BAL3, B-AGGRESSIVE LYMPHOMA PROTEIN 3, TRANSFERASE, GLYCOSYLTRANSFERASE, NUCLEUS, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.400 Å )
Citation :

Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening.

Andersson, C.D.,Karlberg, T.,Ekblad, T.  et al.
(2012)  J.Med.Chem.  55 : 7706 - 7718

PubMed: 22823910
DOI: 10.1021/jm300746d

Reaction

Chain : A, B, C, D
UniProt : Q460N3 (PAR15_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide - UniProtKB:Q9UKK3
left-to-right ECO:0000305
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide - UniProtKB:Q9UKK3
left-to-right ECO:0000305