Het-PDB Navi2 (PDB: 4F09)

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Ligands
Code	Name		Style	Show	Link
JAK	2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-D]pyrrolo[2,3-B]pyridine				PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine

Glycosylation
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Download interaction data: 4F09

Code :

4F09 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

Release Data :

2012-07-04

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase JAK2	A	Janus kinase 2, JAK-2
	ec: 2.7.10.2 fragment: UNP residues 833-1132

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: JAK2 kinase domain expression_system_common: Fall armyworm expression_system_vector_type: plasmid

Authors :

Murray, J.M.

Keywords :

JAK2, kinase domain, JH1 domain, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2.

Zak, M.,Mendonca, R.,Balazs, M. et al.
(2012) J.Med.Chem. 55 : 6176 - 6193

Chain :

UniProt :

O60674 (JAK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:7615558, PubMed:9618263
	-	PROSITE-ProRule:PRU10028, PubMed:7615558, PubMed:9618263

PDB ID: 4F09