Brand  (β version)

PDB ID: 4EZ3

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
0S0 4-[(E)-(6-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)diazenyl]benzenesulfonamide PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4EZ3   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : CDK2 in complex with NSC 134199
Release Data : 2012-08-22
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 2 A CDK2, Cell division protein kinase 2, p33 protein kinase
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CDK2, CDKN2
expression_system_strain: TUNER(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pGEX6P-1
Authors : Alam, R., Martin, M., Zhu, J.-Y., Schonbrunn, E.
Keywords : protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2.

Martin, M.P.,Alam, R.,Betzi, S.  et al.
(2012)  Chembiochem  13 : 2128 - 2136

PubMed: 22893598
DOI: 10.1002/cbic.201200316

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
-