Brand  (β version)

PDB ID: 4EY2

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Ligands
Code Name Style Show Link
0RM (2r,4s)-2-{(R)-carboxy[(2,6-dimethoxybenzoyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4EY2   PDBj   RCSB PDB   PDBe
Header : Hydrolase/antibiotic
Title : Crystal structure of NDM-1 bound to hydrolyzed methicillin
Release Data : 2012-08-08
Compound :
mol_id molecule chains synonym
1 Beta-lactamase NDM-1 A,B NDM-1, Metallo-beta-lactamase NDM-1
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli  (taxid:562)
gene: blaNDM-1
Authors : Strynadka, N.C.J., King, D.T.
Keywords : Metallo-Beta-Lactamase, antibiotic, Hydrolase-antibiotic complex
Exp. method : X-RAY DIFFRACTION ( 1.17 Å )
Citation :

New Delhi Metallo-Beta-Lactamase: Structural Insights into Beta-Lactam Recognition and Inhibition

King, D.T.,Worrall, L.J.,Gruninger, R.  et al.
(2012)  J.Am.Chem.Soc.  134 : 11362 - 11365

PubMed: 22713171
DOI: 10.1021/ja303579d

Reaction

Chain : A, B
UniProt : C7C422 (BLAN1_KLEPN)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PubMed:19770275
-
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:22713171
ECO:0000269 | PubMed:25815530
Binds 2 Zn(2+) ions per subunit.