Brand  (β version)

PDB ID: 4EWS

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Ligands
Code Name Style Show Link
0RP Ethyl (2r,4s)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2h )-carboxylate PoSSuM
2OB Cholesteryl oleate PoSSuM
CL Chloride ion PoSSuM
DLP 1,2-dilinoleoyl-sn-glycero-3-phosphocholine PoSSuM
PGE Triethylene glycol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
FUC Alpha-L-fucopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 4EWS   PDBj   RCSB PDB   PDBe
Header : LIPID TRANSPORT/INHIBITOR
Title : Crystal structure of cholesteryl ester transfer protein in complex with inhibitors
Release Data : 2012-09-05
Compound :
mol_id molecule chains
1 CETP A
Source :
mol_id organism_scientific expression_system
1 Homo sapiens  (taxid:9606) Cricetulus griseus  (taxid:10029)
expression_system_common: Chinese hamster
expression_system_cell_line: DG44
Authors : Liu, S., Qiu, X.
Keywords : Cholestryl Ester Transfer Protein, high-density lipoprotein, low-density lipoprotein, Cholestryl Ester Transfer Protein-INHIBITOR complex, LIPID TRANSPORT-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.59 Å )
Citation :

Crystal structures of cholesteryl ester transfer protein in complex with inhibitors.

Liu, S.,Mistry, A.,Reynolds, J.M.  et al.
(2012)  J.Biol.Chem.  287 : 37321 - 37329

PubMed: 22961980
DOI: 10.1074/jbc.M112.380063

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules.

Qiu, X.,Mistry, A.,Ammirati, M.J.  et al.
(2007)  Nat.Struct.Mol.Biol.  14 : 106 - 113

PubMed: 17237796
DOI: 10.1038/nsmb1197

Reaction

Chain : A
UniProt : P11597 (CETP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z- octadecenoate)(out) - PubMed:24293641
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1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z- octadecenoyl)-glycerol(out) - PubMed:24293641, PubMed:3281933
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cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl (9Z,12Z)-octadecadienoate(out) - PubMed:3281933
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