Het-PDB Navi2 (PDB: 4EWN)

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Ligands
Code	Name		Style	Show	Link
0VR	1-(O-carboxy-phenylamino)-1-deoxy-D-ribulose-5-phosphate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4EWN

Code :

4EWN PDBj RCSB PDB PDBe

Header :

LYASE

Title :

Structure of HisF-D130V+D176V with bound rCdRP

Release Data :

2012-12-05

Compound :

mol_id	molecule	chains	synonym
1	Imidazole glycerol phosphate synthase subunit HisF	D	IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF
	ec: 4.1.3.- mutation: D130V-D176V

Source :

mol_id	organism_scientific	expression_system
1	Thermotoga maritima (taxid:2336)	Escherichia coli (taxid:562)
	gene: hisF, TM_1036 expression_system_vector_type: plasmid expression_system_plasmid: pET

Authors :

Reisinger, B., Bocola, M., Rajendran, C., List, F., Sterner, R.

Keywords :

LYASE

Exp. method :

X-RAY DIFFRACTION ( 1.903 Å )

Citation :

A sugar isomerization reaction established on various (beta-alpha)8-barrel scaffolds is based on substrate-assisted catalysis

Reisinger, B.,Bocola, M.,List, F. et al.
(2012) Protein Eng.Des.Sel. 25 : 751 - 760

Chain :

UniProt :

Q9X0C6 (HIS6_THEMA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5- phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5- amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D- erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate	4.3.2.10	-
	-	-

PDB ID: 4EWN