Brand  (β version)

PDB ID: 4EST

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
VAI (2s)-2-amino-3-methylbutane-1,1-diol
Glycosylation
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Modification
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ACE Acetyl group
FPA Bromo(difluoro)acetic acid
PEA 2-phenylethylamine

Structure summary

Code : 4EST   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION
Release Data : 1992-04-15
Compound :
mol_id molecule chains
1 ELASTASE E
ec: 3.4.21.36
mol_id molecule chains
2 INHIBITOR ACE-ALA-PRO-VAI-DIFLUORO-N-PHENYLETHYLACETAMIDE I
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
tissue: PANCREAS
mol_id organism_scientific
2
synthetic: yes
Authors : Takahashi, L.H., Radhakrishnan, R., Rosenfieldjunior, R.E., Meyerjunior, E.F., Trainor, D.A.
Keywords : SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.78 Å )
Citation :

Crystal Structure of the Covalent Complex Formed by a Peptidyl Alpha,Alpha-Difluoro-Beta-Keto Amide with Porcine Pancreatic Elastase at 1.78-Angstroms Resolution

Takahashi, L.H.,Radhakrishnan, R.,Rosenfieldjunior, R.E.  et al.
(1989)  J.Am.Chem.Soc.  111 : 3368

PubMed: -1

Structure of Native Porcine Pancreatic Elastase at 1.65 Angstroms Resolution

Meyer, E.,Cole, G.,Radhakrishnan, R.  et al.
(1988)  Acta Crystallogr.,Sect.B  44 : 26

Reaction

Chain : E
UniProt : P00772 (CELA1_PIG)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa. 3.4.21.36 PubMed:5415108
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