Het-PDB Navi2 (PDB: 4ESI)

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Ligands
Code	Name		Style	Show	Link
0RB	2-amino-4-oxo-N-(1h-1,2,3-triazol-5-ylmethyl)-1,4-dihydropteridine-7-carboxamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4ESI

Code :

4ESI PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Structure of ricin A chain bound with N-((1H-1,2,3-triazol-4-yl)methyl-2-amino-4-oxo-3,4-dihydropteridine-7-carboxamide

Release Data :

2012-10-31

Compound :

mol_id	molecule	chains	synonym
1	Ricin	A	Ricin A chain, rRNA N-glycosidase, Linker peptide
	ec: 3.2.2.22

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Ricinus communis (taxid:3988)	Castor bean	Escherichia coli (taxid:562)
	expression_system_strain: JM101 expression_system_vector_type: plasmid expression_system_plasmid: PUTA

Authors :

Jasheway, K.R., Pruet, J.M., Ryoto, S., Manzano, L.A., Wiget, P.A., Kamat, I., Anslyn, E.V., Monzingo, A.F., Robertus, J.D.

Keywords :

RICIN, TOXIN, PROTEIN-LIGAND COMPLEX, HYDROLASE, RIBOSOME INACTIVATING PROTEIN, N-GLYCOSIDASE, PTERIN, HYDROLASE-INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.8700 Å )

Citation :

Optimized 5-membered heterocycle-linked pterins for the inhibition of Ricin Toxin A.

Pruet, J.M.,Saito, R.,Manzano, L.A. et al.
(2012) ACS Med Chem Lett 3 : 588 - 591

PubMed: 23050058
DOI: 10.1021/ml300099t

Chain :

UniProt :

P02879 (RICI_RICCO)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
[Ricin A chain] Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.	3.2.2.22	-
	-	-

PDB ID: 4ESI

Hetero Atom Contents

Structure summary

Reaction