Brand  (β version)

PDB ID: 4ERF

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Ligands
Code Name Style Show Link
0R3 {(3r,5r,6s)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2s,3s)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl}acetic acid PoSSuM
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Structure summary

Code : 4ERF   PDBj   RCSB PDB   PDBe
Header : Ligase/Ligase inhibitor
Title : crystal structure of MDM2 (17-111) in complex with compound 29 (AM-8553)
Release Data : 2012-05-23
Compound :
mol_id molecule chains synonym
1 E3 ubiquitin-protein ligase Mdm2 A,C,E Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2
ec: 6.3.2.-
fragment: unp residues 17-111
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MDM2
Authors : Huang, X.
Keywords : MDM2, p53, protein protein interaction, Ligase-Ligase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Structure-based design of novel inhibitors of the MDM2-p53 interaction.

Rew, Y.,Sun, D.,Gonzalez-Lopez De Turiso, F.  et al.
(2012)  J.Med.Chem.  55 : 4936 - 4954

PubMed: 22524527
DOI: 10.1021/jm300354j

Reaction

Chain : A, C, E
UniProt : Q00987 (MDM2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. 2.3.2.27 PubMed:12821780
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