Het-PDB Navi2 (PDB: 4EPV)

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Ligands
Code	Name	Link
0QX	2-(1h-indol-3-ylmethyl)-1h-imidazo[4,5-C]pyridine	PoSSuM
GDP	Guanosine-5'-diphosphate	PoSSuM
MG	Magnesium ion	PoSSuM

Non-standard Residues
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Download interaction data: 4EPV

Code :

4EPV PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation

Release Data :

2012-05-23

Compound :

mol_id	molecule	chains	synonym
1	GTPase KRas	A	K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, GTPase KRas, N-terminally processed
	ec: 3.6.5.2 mutation: C118S

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: KRAS, KRAS2, RASK2

Authors :

Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W.

Keywords :

small GTPase, Signaling transduction, Sos, Raf, Ral, PI3K, cytosol, binder, HYDROLASE, Inhibitor of Sos-mediated activation

Exp. method :

X-RAY DIFFRACTION ( 1.35 Å )

Citation :

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.

Sun, Q.,Burke, J.P.,Phan, J. et al.
(2012) Angew.Chem.Int.Ed.Engl. 51 : 6140 - 6143

Chain :

UniProt :

P01116 (RASK_HUMAN)

PDB ID: 4EPV