Brand  (β version)

PDB ID: 4EOX

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
0S5 N-benzoyl-1-[(2r)-3-cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl]-L-prolinamide PoSSuM
NI Nickel (II) ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4EOX   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor
Release Data : 2012-05-30
Compound :
mol_id molecule chains synonym
1 Peptide deformylase P PDF, Polypeptide deformylase
ec: 3.5.1.88
Source :
mol_id organism_scientific expression_system
1 Streptococcus pneumoniae  (taxid:171101) Escherichia coli  (taxid:562)
strain: ATCC BAA-255 / R6
gene: def, spr1310
Authors : Ward, P., Campobasso, N.
Keywords : Alpha-beta, peptide deformylase metal ion binding, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.783 Å )
Citation :

Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.

Axten, J.M.,Medina, J.R.,Blackledge, C.W.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 4028 - 4032

PubMed: 22579486
DOI: 10.1016/j.bmcl.2012.04.086

Reaction

Chain : P
UniProt : Q8DP79 (DEF_STRR6)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N- terminal L-methionyl-[peptide] 3.5.1.88 HAMAP-Rule:MF_00163
-