PDB ID: 4EKI
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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0QK | 7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7h-pyrrolo[2,3-D]pyrimidin-4-amine | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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Download interaction data: 4EKI
Structure summary
Code : | 4EKI PDBj RCSB PDB PDBe | ||||||||||||
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Header : | transferase/transferase inhibitor | ||||||||||||
Title : | Crystal Structure of DOT1L in complex with EPZ004777 | ||||||||||||
Release Data : | 2012-10-17 | ||||||||||||
Compound : |
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Source : |
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Authors : | Jin, L. | ||||||||||||
Keywords : | methyltransferase, transferase-transferase inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.85 Å ) | ||||||||||||
Citation : |
Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L.
Basavapathruni, A.,Jin, L.,Daigle, S.R.
et al.
PubMed: 22978415 |
Reaction
Chain : | A | ||||||||
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UniProt : | Q8TEK3 (DOT1L_HUMAN) | ||||||||
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