PDB ID: 4EKG
Hetero Atom Contents
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Structure summary
Code : | 4EKG PDBj RCSB PDB PDBe | ||||||||||||
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Header : | transferase/transferase inhibitor | ||||||||||||
Title : | Crystal Structure of DOT1L in Complex with EPZ003696 | ||||||||||||
Release Data : | 2012-10-17 | ||||||||||||
Compound : |
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Source : |
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Authors : | Jin, L. | ||||||||||||
Keywords : | methyltransferase, transferase-transferase inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.80 Å ) | ||||||||||||
Citation : |
Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L.
Basavapathruni, A.,Jin, L.,Daigle, S.R.
et al.
PubMed: 22978415 |
Reaction
Chain : | A | ||||||||
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UniProt : | Q8TEK3 (DOT1L_HUMAN) | ||||||||
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